Low Expression Of PP2A Regulatory Subunit B55α Is Associated With T308 Phosphorylation Of AKT And Shorter Complete Remission Duration In Acute Myeloid Leukemia Patients

The regulation of Protein Kinase B (AKT) is a dynamic process that depends on the balance between phosphorylation by upstream kinases for activation and inactivation by dephosphorylation by protein phosphatases. Phosphorylated AKT is commonly found in acute myeloid leukemia (AML) and confers an unfa...

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Hlavní autoři: Ruvolo, Peter P., Qui, YiHua, Coombes, Kevin R., Zhang, Nianxiang, Ruvolo, Vivian R., Borthakur, Gautam, Konopleva, Marina, Andreeff, Michael, Kornblau, Steven M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191228/
https://ncbi.nlm.nih.gov/pubmed/21660042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.146
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