Human FasL Gene Is a Target of β-Catenin/T-Cell Factor Pathway and Complex FasL Haplotypes Alter Promoter Functions

FasL expression on human immune cells and cancer cells plays important roles in immune homeostasis and in cancer development. Our previous study suggests that polymorphisms in the FasL promoter can significantly affect the gene expression in human cells. In addition to the functional FasL SNP -844C&...

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Main Authors: Wu, Jianming, Richards, Maureen H., Huang, Jinhai, Al-Harthi, Lena, Xu, Xiulong, Lin, Rui, Xie, Fenglong, Gibson, Andrew W., Edberg, Jeffrey C., Kimberly, Robert P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191176/
https://ncbi.nlm.nih.gov/pubmed/22022540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026143
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