Extracellular proton depression of peak and late Na(+) current in the canine left ventricle

Cardiac ischemia reduces excitability in ventricular tissue. Acidosis (one component of ischemia) affects a number of ion currents. We examined the effects of extracellular acidosis (pH 6.6) on peak and late Na(+) current (I(Na)) in canine ventricular cells. Epicardial and endocardial myocytes were...

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Bibliografiske detaljer
Main Authors: Murphy, Lisa, Renodin, Danielle, Antzelevitch, Charles, Di Diego, José M., Cordeiro, Jonathan M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2011
Fag:
Cardiac Excitation and Contraction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191105/
https://ncbi.nlm.nih.gov/pubmed/21685271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00204.2011
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