Glucan phosphate attenuates myocardial HMGB1 translocation in severe sepsis through inhibiting NF-κB activation

Myocardial dysfunction is a major consequence of septic shock and contributes to the high mortality of sepsis. High-mobility group box 1 (HMGB1) serves as a late mediator of lethality in sepsis. We have reported that glucan phosphate (GP) attenuates cardiac dysfunction and increases survival in ceca...

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Detalhes bibliográficos
Main Authors: Ha, Tuanzhu, Xia, Yeling, Liu, Xiang, Lu, Chen, Liu, Li, Kelley, Jim, Kalbfleisch, John, Kao, Race L., Williams, David L., Li, Chuanfu
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Signaling and Stress Response
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191099/
https://ncbi.nlm.nih.gov/pubmed/21642503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01007.2010
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