SPARC regulates collagen interaction with cardiac fibroblast cell surfaces

Cardiac tissue from mice that do not express secreted protein acidic and rich in cysteine (SPARC) have reduced amounts of insoluble collagen content at baseline and in response to pressure overload hypertrophy compared with wild-type (WT) mice. However, the cellular mechanism by which SPARC affects...

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Bibliographic Details
Main Authors: Harris, Brett S., Zhang, Yuhua, Card, Lauren, Rivera, Lee B., Brekken, Rolf A., Bradshaw, Amy D.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
Subjects:
Signaling and Stress Response
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191098/
https://ncbi.nlm.nih.gov/pubmed/21666116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01247.2010
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