Glycogen Synthase Kinase-3β (GSK3β) Negatively Regulates PTTG1/Human Securin Protein Stability, and GSK3β Inactivation Correlates with Securin Accumulation in Breast Tumors

PTTG1, also known as securin, is an inactivating partner of separase, the major effector for chromosome segregation during mitosis. At the metaphase-to-anaphase transition, securin is targeted for proteasomal destruction by the anaphase-promoting complex or cyclosome, allowing activation of separase...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mora-Santos, Mar, Limón-Mortés, M. Cristina, Giráldez, Servando, Herrero-Ruiz, Joaquín, Sáez, Carmen, Japón, Miguel Á., Tortolero, Maria, Romero, Francisco
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191045/
https://ncbi.nlm.nih.gov/pubmed/21757741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.232330
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