Mechanism and Specificity of Pentachloropseudilin-mediated Inhibition of Myosin Motor Activity

Here, we report that the natural compound pentachloropseudilin (PClP) acts as a reversible and allosteric inhibitor of myosin ATPase and motor activity. IC(50) values are in the range from 1 to 5 μm for mammalian class-1 myosins and greater than 90 μm for class-2 and class-5 myosins, and no inhibiti...

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Hauptverfasser: Chinthalapudi, Krishna, Taft, Manuel H., Martin, René, Heissler, Sarah M., Preller, Matthias, Hartmann, Falk K., Brandstaetter, Hemma, Kendrick-Jones, John, Tsiavaliaris, Georgios, Gutzeit, Herwig O., Fedorov, Roman, Buss, Folma, Knölker, Hans-Joachim, Coluccio, Lynne M., Manstein, Dietmar J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191011/
https://ncbi.nlm.nih.gov/pubmed/21680745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.239210
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