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Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C
Despite a generic, highly conserved motor domain, ATP turnover kinetics and their activation by F-actin vary greatly between myosin-2 isoforms. Here, we present a 2.25 Å pre-powerstroke state (ADP⋅VO(4)) crystal structure of the human nonmuscle myosin-2C motor domain, one of the slowest myosins char...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5749951/ https://ncbi.nlm.nih.gov/pubmed/29256864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32742 |
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