Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C

Despite a generic, highly conserved motor domain, ATP turnover kinetics and their activation by F-actin vary greatly between myosin-2 isoforms. Here, we present a 2.25 Å pre-powerstroke state (ADP⋅VO(4)) crystal structure of the human nonmuscle myosin-2C motor domain, one of the slowest myosins char...

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Bibliographic Details
Published in:eLife
Main Authors: Chinthalapudi, Krishna, Heissler, Sarah M, Preller, Matthias, Sellers, James R, Manstein, Dietmar J
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Structural Biology and Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749951/
https://ncbi.nlm.nih.gov/pubmed/29256864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32742
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