Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation

The asparaginyl hydroxylase, factor-inhibiting hypoxia-inducible factor (HIF), is central to the oxygen-sensing pathway that controls the activity of HIF. Factor-inhibiting HIF (FIH) also catalyzes the hydroxylation of a large set of proteins that share a structural motif termed the ankyrin repeat d...

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Autores principales: Singleton, Rachelle S., Trudgian, David C., Fischer, Roman, Kessler, Benedikt M., Ratcliffe, Peter J., Cockman, Matthew E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190818/
https://ncbi.nlm.nih.gov/pubmed/21808058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.262808
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