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ATP Potentiates Competitive Inhibition of Guanylyl Cyclase A and B by the Staurosporine Analog, Gö6976: RECIPROCAL REGULATION OF ATP AND GTP BINDING

Natriuretic peptides and ATP activate and Gö6976 inhibits guanylyl cyclase (GC)-A and GC-B. Here, the mechanism of inhibition was determined. Gö6976 progressively increased the Michaelis-Menten constant and decreased the Hill coefficient without reducing the maximal velocity of GC-A and GC-B. In the...

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Bibliografische gegevens
Hoofdauteurs: Robinson, Jerid W., Potter, Lincoln R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2011
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190780/
https://ncbi.nlm.nih.gov/pubmed/21828054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.273565
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