Загрузка...

ATP Potentiates Competitive Inhibition of Guanylyl Cyclase A and B by the Staurosporine Analog, Gö6976: RECIPROCAL REGULATION OF ATP AND GTP BINDING

Natriuretic peptides and ATP activate and Gö6976 inhibits guanylyl cyclase (GC)-A and GC-B. Here, the mechanism of inhibition was determined. Gö6976 progressively increased the Michaelis-Menten constant and decreased the Hill coefficient without reducing the maximal velocity of GC-A and GC-B. In the...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Robinson, Jerid W., Potter, Lincoln R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190780/
https://ncbi.nlm.nih.gov/pubmed/21828054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.273565
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!