The Extracellular Regulated Kinase-1 (ERK1) Controls Regulated α-Secretase-mediated Processing, Promoter Transactivation, and mRNA Levels of the Cellular Prion Protein

The α-secretases A disintegrin and metalloprotease 10 (ADAM10) and ADAM17 trigger constitutive and regulated processing of the cellular prion protein (PrP(c)) yielding N1 fragment. The latter depends on protein kinase C (PKC)-coupled M1/M3 muscarinic receptor activation and subsequent phosphorylatio...

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Hlavní autoři: Cissé, Moustapha, Duplan, Eric, Guillot-Sestier, Marie-Victoire, Rumigny, Joaquim, Bauer, Charlotte, Pagès, Gilles, Orzechowski, Hans-Dieter, Slack, Barbara E., Checler, Frédéric, Vincent, Bruno
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190726/
https://ncbi.nlm.nih.gov/pubmed/21586567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.208249
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