PG12, a Phospholipid Analog with Potent Antimalarial Activity, Inhibits Plasmodium falciparum CTP:Phosphocholine Cytidylyltransferase Activity

In the human malaria parasite Plasmodium falciparum, the synthesis of the major and essential membrane phospholipid, phosphatidylcholine, occurs via the CDP-choline and the serine decarboxylase phosphoethanolamine methylation (SDPM) pathways, which are fueled by host choline, serine, and fatty acids...

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Bibliographische Detailangaben
Hauptverfasser: González-Bulnes, Patricia, Bobenchik, April M., Augagneur, Yoann, Cerdan, Rachel, Vial, Henri J., Llebaria, Amadeu, Ben Mamoun, Choukri
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Lipids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190701/
https://ncbi.nlm.nih.gov/pubmed/21705805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.268946
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