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Alternative Pathways for Radical Dissipation in an Active Site Mutant of B(12)-dependent Methylmalonyl-CoA Mutase()

Methylmalonyl-CoA mutase catalyzes the adenosylcobalamin-dependent rearrangement of (2R)-methylmalonyl-CoA to succinyl-CoA. The crystal structure of the enzyme reveals that Y243 is in van der Waals contact with the methyl group of the substrate and suggests a possible role for it in the stereochemic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Padovani, Dominique, Banerjee, Ruma
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190604/
https://ncbi.nlm.nih.gov/pubmed/16503649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi051742d
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