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Decreased TCR signaling through Card11 differentially compromises Foxp3+ regulatory versus Th2 effector cells to cause allergy
BACKGROUND: Allergy, the most common disease of immune dysregulation, has a substantial genetic component that is poorly understood. While complete disruption of TCR signaling causes profound immunodeficiency, little is known about the consequences of inherited genetic variants that cause partial, q...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3189857/ https://ncbi.nlm.nih.gov/pubmed/21320717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2010.12.1081 |
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