Pharmacogenetics of OATP Transporters Reveals That SLCO1B1 c.388A>G Variant Is Determinant of Increased Atorvastatin Response

AIMS: The relationship between variants in SLCO1B1 and SLCO2B1 genes and lipid-lowering response to atorvastatin was investigated. MATERIAL AND METHODS: One-hundred-thirty-six unrelated individuals with hypercholesterolemia were selected and treated with atorvastatin (10 mg/day/4 weeks). They were g...

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Main Authors: Rodrigues, Alice C., Perin, Paula M. S., Purim, Sheila G., Silbiger, Vivian N., Genvigir, Fabiana D. V., Willrich, Maria Alice V., Arazi, Simone S., Luchessi, Andre D., Hirata, Mario H., Bernik, Marcia M. S., Dorea, Egidio L., Santos, Carla, Faludi, Andre A., Bertolami, Marcelo C., Salas, Antonio, Freire, Ana, Lareu, Maria V., Phillips, Christopher, Porras-Hurtado, Liliana, Fondevila, Manuel, Carracedo, Angel, Hirata, Rosario D. C.
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Diversity Preservation International (MDPI) 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189752/
https://ncbi.nlm.nih.gov/pubmed/22016628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms12095815
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