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The role of calcium ions in the stability and instability of a thermolysin-like protease

Thermolysin and other secreted broad-specificity proteases, such as subtilisin or alpha-lytic protease, are produced as pre-pro-proteins that stay at least partially unfolded while in the cytosol. After secretion, the pro-proteases fold to their active conformations in a process that includes the au...

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Autori principali: Eijsink, VGH, Matthews, BW, Vriend, G
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley Subscription Services, Inc., A Wiley Company 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189520/
https://ncbi.nlm.nih.gov/pubmed/21648000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.670
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