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Balancing eukaryotic replication asymmetry with replication fidelity

Coordinated replication of eukaryotic nuclear genomes is asymmetric, with copying of a leading strand template preceding discontinuous copying of the lagging strand template. Replication is catalyzed by DNA polymerases α, δ and ε, enzymes that are related yet differ in physical and biochemical prope...

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Autor principal: Kunkel, Thomas A.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189284/
https://ncbi.nlm.nih.gov/pubmed/21862387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2011.07.025
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