Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats

Systemic administration of the mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) was previously shown to selectively attenuate nicotine self-administration without affecting food-maintained responding in rats. Glutamatergic neurotransmission in the ventral tegmental area (VTA) and...

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Detaylı Bibliyografya
Asıl Yazarlar: D'Souza, Manoranjan S., Markou, Athina
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189265/
https://ncbi.nlm.nih.gov/pubmed/21896278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2011.08.028
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