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Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
BACKGROUND: Memory deficits in Alzheimer's disease (AD) manifest together with the loss of synapses caused by the disruption of the postsynaptic density (PSD), a network of scaffold proteins located in dendritic spines. However, the underlying molecular mechanisms remain elusive. Since it was s...
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Główni autorzy: | , , , , , , , , , , |
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Format: | Artigo |
Język: | Inglês |
Wydane: |
BioMed Central
2011
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3189132/ https://ncbi.nlm.nih.gov/pubmed/21939532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-65 |
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