N-O Chemistry for Antibiotics: Discovery of N-Alkyl-N-(pyridin-2-yl)hydroxylamine Scaffolds as Selective Antibacterial Agents Using Nitroso Diels-Alder and Ene Chemistry

The discovery, syntheses, and structure-activity relationships (SAR) of a new family of heterocyclic antibacterial compounds based on N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds are described. A structurally diverse library of ~100 heterocyclic molecules generated from Lewis acid-mediated nucleo...

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Bibliographic Details
Main Authors: Wencewicz, Timothy A., Yang, Baiyuan, Rudloff, James R., Oliver, Allen G., Miller, Marvin J.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188665/
https://ncbi.nlm.nih.gov/pubmed/21859126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200794r
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