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Structural and Biochemical Studies of Human 4-hydroxy-2-oxoglutarate Aldolase: Implications for Hydroxyproline Metabolism in Primary Hyperoxaluria

BACKGROUND: 4-hydroxy-2-oxoglutarate (HOG) aldolase is a unique enzyme in the hydroxyproline degradation pathway catalyzing the cleavage of HOG to pyruvate and glyoxylate. Mutations in this enzyme are believed to be associated with the excessive production of oxalate in primary hyperoxaluria type 3...

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書誌詳細
主要な著者: Riedel, Travis J., Johnson, Lynnette C., Knight, John, Hantgan, Roy R., Holmes, Ross P., Lowther, W. Todd
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188589/
https://ncbi.nlm.nih.gov/pubmed/21998747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026021
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