Role of tumor–host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors

The large size of many novel therapeutics impairs their transport through the tumor extracellular matrix and thus limits their therapeutic effectiveness. We propose that extracellular matrix composition, structure, and distribution determine the transport properties in tumors. Furthermore, because t...

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में प्रकाशित:	Proc Natl Acad Sci U S A
मुख्य लेखकों:	Pluen, Alain, Boucher, Yves, Ramanujan, Saroja, McKee, Trevor D., Gohongi, Takeshi, di Tomaso, Emmanuelle, Brown, Edward B., Izumi, Yotaro, Campbell, Robert B., Berk, David A., Jain, Rakesh K.
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	National Academy of Sciences 2001
विषय:	Biological Sciences
ऑनलाइन पहुंच:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274375/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.081626898
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