Role of tumor–host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors

The large size of many novel therapeutics impairs their transport through the tumor extracellular matrix and thus limits their therapeutic effectiveness. We propose that extracellular matrix composition, structure, and distribution determine the transport properties in tumors. Furthermore, because t...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Pluen, Alain, Boucher, Yves, Ramanujan, Saroja, McKee, Trevor D., Gohongi, Takeshi, di Tomaso, Emmanuelle, Brown, Edward B., Izumi, Yotaro, Campbell, Robert B., Berk, David A., Jain, Rakesh K.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 2001
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274375/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.081626898
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