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Role of tumor–host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors
The large size of many novel therapeutics impairs their transport through the tumor extracellular matrix and thus limits their therapeutic effectiveness. We propose that extracellular matrix composition, structure, and distribution determine the transport properties in tumors. Furthermore, because t...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2001
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC31885/ https://ncbi.nlm.nih.gov/pubmed/11274375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081626898 |
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