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Change in Allosteric Network Affects Binding Affinities of PDZ Domains: Analysis through Perturbation Response Scanning

The allosteric mechanism plays a key role in cellular functions of several PDZ domain proteins (PDZs) and is directly linked to pharmaceutical applications; however, it is a challenge to elaborate the nature and extent of these allosteric interactions. One solution to this problem is to explore the...

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Autors principals: Gerek, Z. Nevin, Ozkan, S. Banu
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188487/
https://ncbi.nlm.nih.gov/pubmed/21998559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002154
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