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Influence of Ethanol and Gender on Methylphenidate Pharmacokinetics and Pharmacodynamics
This study explores the hypotheses that: (1) ethanol will interact with dl-Methylphenidate (MPH) to enantioselectively elevate plasma d-MPH, and primarily yield l-ethylphenidate as a transesterification metabolite; (2) women will exhibit lower relative bioavailability of MPH than men; and (3) sex-de...
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| Glavni autori: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3188424/ https://ncbi.nlm.nih.gov/pubmed/17339864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.clpt.6100082 |
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