High-Resolution Melting Approach to Efficient Identification and Quantification of H275Y Mutant Influenza H1N1/2009 Virus in Mixed-Virus-Population Samples

The single-nucleotide variation 823C to T (His275Tyr), responsible for oseltamivir drug resistance has been detected in some isolates of the influenza A/H1N1/2009 virus. Early detection of the presence of this oseltamivir-resistant strain allows prompt consideration of alternative treatment options....

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Bibliographic Details
Main Authors: Lee, Hong Kai, Lee, Chun Kiat, Loh, Tze Ping, Tang, Julian Wei-Tze, Tambyah, Paul Anantharajah, Koay, Evelyn Siew-Chuan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Virology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187298/
https://ncbi.nlm.nih.gov/pubmed/21865430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.01087-11
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