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High-Resolution Melting Approach to Efficient Identification and Quantification of H275Y Mutant Influenza H1N1/2009 Virus in Mixed-Virus-Population Samples

The single-nucleotide variation 823C to T (His275Tyr), responsible for oseltamivir drug resistance has been detected in some isolates of the influenza A/H1N1/2009 virus. Early detection of the presence of this oseltamivir-resistant strain allows prompt consideration of alternative treatment options....

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Autors principals: Lee, Hong Kai, Lee, Chun Kiat, Loh, Tze Ping, Tang, Julian Wei-Tze, Tambyah, Paul Anantharajah, Koay, Evelyn Siew-Chuan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187298/
https://ncbi.nlm.nih.gov/pubmed/21865430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.01087-11
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