Comparative (13)C Metabolic Flux Analysis of Pyruvate Dehydrogenase Complex-Deficient, l-Valine-Producing Corynebacterium glutamicum

l-Valine can be formed successfully using C. glutamicum strains missing an active pyruvate dehydrogenase enzyme complex (PDHC). Wild-type C. glutamicum and four PDHC-deficient strains were compared by (13)C metabolic flux analysis, especially focusing on the split ratio between glycolysis and the pe...

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Hauptverfasser: Bartek, Tobias, Blombach, Bastian, Lang, Siegmund, Eikmanns, Bernhard J., Wiechert, Wolfgang, Oldiges, Marco, Nöh, Katharina, Noack, Stephan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Biotechnology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187166/
https://ncbi.nlm.nih.gov/pubmed/21784914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00575-11
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