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Endocytosis-Mediated Vacuolar Accumulation of the Human ApoE Apolipoprotein-Derived ApoEdpL-W Antimicrobial Peptide Contributes to Its Antifungal Activity in Candida albicans

The 18-amino-acid cationic, tryptophan-rich ApoEdpL-W peptide derived from human ApoE apolipoprotein was shown to have antifungal activity against pathogenic yeasts of the Candida genus (except C. glabrata). ApoEdpL-W was active against planktonic cells and early-stage biofilms but less active again...

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Autori principali: Rossignol, Tristan, Kelly, Bridie, Dobson, Curtis, d'Enfert, Christophe
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186967/
https://ncbi.nlm.nih.gov/pubmed/21807970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00319-11
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