Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor

Brain protection of the newborn remains a challenging priority and represents a totally unmet medical need. Pharmacological inhibition of caspases appears as a promising strategy for neuroprotection. In a translational perspective, we have developed a pentapeptide-based group II caspase inhibitor, T...

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Bibliographic Details
Main Authors: Chauvier, D, Renolleau, S, Holifanjaniaina, S, Ankri, S, Bezault, M, Schwendimann, L, Rousset, C, Casimir, R, Hoebeke, J, Smirnova, M, Debret, G, Trichet, A-P, Carlsson, Y, Wang, X, Bernard, E, Hébert, M, Rauzier, J-M, Matecki, S, Lacampagne, A, Rustin, P, Mariani, J, Hagberg, H, Gressens, P, Charriaut-Marlangue, C, Jacotot, E
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186905/
https://ncbi.nlm.nih.gov/pubmed/21881605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.87
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