Suppression of 5′-Nucleotidase Enzymes Promotes AMP-activated Protein Kinase (AMPK) Phosphorylation and Metabolism in Human and Mouse Skeletal Muscle

The 5′-nucleotidase (NT5) family of enzyme dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates. We hypothesized that gene silencing of NT5 enzymes to increase the intracellular availability of AMP would increase AMP-activated protein kinase (AMPK) ac...

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Détails bibliographiques
Auteurs principaux: Kulkarni, Sameer S., Karlsson, Håkan K. R., Szekeres, Ferenc, Chibalin, Alexander V., Krook, Anna, Zierath, Juleen R.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Metabolism
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186409/
https://ncbi.nlm.nih.gov/pubmed/21873433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.268292
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