Substrate tRNA Recognition Mechanism of a Multisite-specific tRNA Methyltransferase, Aquifex aeolicus Trm1, Based on the X-ray Crystal Structure

Archaeal and eukaryotic tRNA (N(2),N(2)-guanine)-dimethyltransferase (Trm1) produces N(2),N(2)-dimethylguanine at position 26 in tRNA. In contrast, Trm1 from Aquifex aeolicus, a hyper-thermophilic eubacterium, modifies G27 as well as G26. Here, a gel mobility shift assay revealed that the T-arm in t...

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Detalhes bibliográficos
Main Authors: Awai, Takako, Ochi, Anna, Ihsanawati, Sengoku, Toru, Hirata, Akira, Bessho, Yoshitaka, Yokoyama, Shigeyuki, Hori, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186374/
https://ncbi.nlm.nih.gov/pubmed/21844194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.253641
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