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Spontaneous and Engineered Compensatory HSV Mutants that Counteract the Host Antiviral PKR Response
A virulent recombinant HSV lacking the diploid γ(1)34.5 gene (Δγ(1)34.5) have been investigated over the last two decades both for anti-tumor therapy and as vaccine vectors. The first generation vectors, while safe, are incapable of sustained replication in the majority of treated patients. An inter...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Molecular Diversity Preservation International (MDPI)
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3185541/ https://ncbi.nlm.nih.gov/pubmed/21994558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v1030510 |
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