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STEME: efficient EM to find motifs in large data sets

MEME and many other popular motif finders use the expectation–maximization (EM) algorithm to optimize their parameters. Unfortunately, the running time of EM is linear in the length of the input sequences. This can prohibit its application to data sets of the size commonly generated by high-throughp...

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Detalhes bibliográficos
Main Authors: Reid, John E., Wernisch, Lorenz
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185442/
https://ncbi.nlm.nih.gov/pubmed/21785132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr574
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