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Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription
Autoimmune regulator (AIRE) is a transcription factor that induces the expression of a large subset of otherwise strictly tissue restricted antigens in medullary thymic epithelial cells, thereby enabling their presentation to developing T cells for negative selection. Mutations in AIRE lead to autoi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3185428/ https://ncbi.nlm.nih.gov/pubmed/21724609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr527 |
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