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Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation

Jaagsiekte sheep retrovirus (JSRV) can induce rapid, multifocal lung cancer, but JSRV is a simple retrovirus having no known oncogenes. Here we show that the envelope (env) gene of JSRV has the unusual property that it can induce transformation in rat fibroblasts, and thus is likely to be responsibl...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Rai, Sharath K., Duh, Fuh-Mei, Vigdorovich, Vladimir, Danilkovitch-Miagkova, Alla, Lerman, Michael I., Miller, A. Dusty
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31854/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11296287/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.071572898
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