LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

R-spondins are secreted Wnt signalling agonists, which regulate embryonic patterning and stem cell proliferation, but whose mechanism of action is poorly understood. Here we show that R-spondins bind to the orphan G-protein-coupled receptors LGR4 and LGR5 by their Furin domains. Gain- and loss-of-fu...

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Main Authors: Glinka, Andrei, Dolde, Christine, Kirsch, Nadine, Huang, Ya-Lin, Kazanskaya, Olga, Ingelfinger, Dierk, Boutros, Michael, Cruciat, Cristina-Maria, Niehrs, Christof
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185347/
https://ncbi.nlm.nih.gov/pubmed/21909076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.175
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