Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/βcatenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek

Dickkopf-1 (Dkk1) is a secreted protein that negatively modulates the Wnt/βcatenin pathway. Lack of Dkk1 function affects head formation in frog and mice, supporting the idea that Dkk1 acts as a “head inducer” during gastrulation. We show here that lack of Dkk1 function accelerates internalization a...

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Detalhes bibliográficos
Main Authors: Caneparo, Luca, Huang, Ya-Lin, Staudt, Nicole, Tada, Masasumi, Ahrendt, Reiner, Kazanskaya, Olga, Niehrs, Christof, Houart, Corinne
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1804334/
https://ncbi.nlm.nih.gov/pubmed/17322405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.406007
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