Alpha Particles Induce Apoptosis through the Sphingomyelin Pathway

The sphingomyelin pathway involves the enzymatic cleavage of sphingomyelin to produce ceramide, a second messenger that serves as a key mediator in the rapid apoptotic response to various cell stressors. Low-linear energy transfer (LET) γ radiation can initiate this pathway, independent of DNA damag...

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Bibliografiske detaljer
Main Authors: Seideman, Jonathan H., Stancevic, Branka, Rotolo, Jimmy A., McDevitt, Michael R., Howell, Roger W., Kolesnick, Richard N., Scheinberg, David A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185310/
https://ncbi.nlm.nih.gov/pubmed/21631289
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