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The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest
Poly(ADP)ribose polymerase (PARP) inhibitors modify the enzymatic activity of PARP1/2. When certain PARP inhibitors are used either alone or in combination with DNA damage agents they may cause a G2/M mitotic arrest and/or apoptosis in a susceptible genetic context. PARP1 interacts with the cell cyc...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3185120/ https://ncbi.nlm.nih.gov/pubmed/21840268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2011.07.006 |
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