Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise

The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood. We used doxorubicin, a widely used cancer chemotherapeutic, in a variety of in vivo xenograft, and in vitro models to investigate the impact of chemotherapy-induced aging on the human ovary. Doxorubicin caus...

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Bibliographic Details
Main Authors: Soleimani, Reza, Heytens, Elke, Darzynkiewicz, Zbigniew, Oktay, Kutluk
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2011
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184979/
https://ncbi.nlm.nih.gov/pubmed/21869459
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