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Light-based feedback for controlling intracellular signaling dynamics

The ability to apply precise inputs to signaling species in live cells would be transformative for interrogating and understanding complex cell signaling systems. Here, we report a method for applying custom signaling inputs using feedback control of an optogenetic protein-protein interaction. We ap...

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Detalles Bibliográficos
Main Authors: Toettcher, Jared E., Gong, Delquin, Lim, Wendell A., Weiner, Orion D.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184382/
https://ncbi.nlm.nih.gov/pubmed/21909100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1700
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