Heritable GATA2 Mutations Associated with Familial Myelodysplastic Syndrome and Acute Myeloid Leukemia

We report the discovery of the GATA2 gene as a new myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) predisposition gene. We found the same, novel heterozygous c.1061C>T (p.Thr354Met) missense mutation in the GATA2 transcription factor gene segregating with the multigenerational transmi...

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Main Authors: Hahn, Christopher N., Chong, Chan-Eng, Carmichael, Catherine L., Wilkins, Ella J., Brautigan, Peter J., Li, Xiao-Chun, Babic, Milena, Lin, Ming, Carmagnac, Amandine, Lee, Young K., Kok, Chung H., Gagliardi, Lucia, Friend, Kathryn L., Ekert, Paul G., Butcher, Carolyn M., Brown, Anna L., Lewis, Ian D., To, L. Bik, Timms, Andrew E., Storek, Jan, Moore, Sarah, Altree, Meryl, Escher, Robert, Bardy, Peter G., Suthers, Graeme K., D’Andrea, Richard J., Horwitz, Marshall S., Scott, Hamish S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184204/
https://ncbi.nlm.nih.gov/pubmed/21892162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.913
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