Heritable GATA2 Mutations Associated with Familial Myelodysplastic Syndrome and Acute Myeloid Leukemia

We report the discovery of the GATA2 gene as a new myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) predisposition gene. We found the same, novel heterozygous c.1061C>T (p.Thr354Met) missense mutation in the GATA2 transcription factor gene segregating with the multigenerational transmi...

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Hoofdauteurs: Hahn, Christopher N., Chong, Chan-Eng, Carmichael, Catherine L., Wilkins, Ella J., Brautigan, Peter J., Li, Xiao-Chun, Babic, Milena, Lin, Ming, Carmagnac, Amandine, Lee, Young K., Kok, Chung H., Gagliardi, Lucia, Friend, Kathryn L., Ekert, Paul G., Butcher, Carolyn M., Brown, Anna L., Lewis, Ian D., To, L. Bik, Timms, Andrew E., Storek, Jan, Moore, Sarah, Altree, Meryl, Escher, Robert, Bardy, Peter G., Suthers, Graeme K., D’Andrea, Richard J., Horwitz, Marshall S., Scott, Hamish S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184204/
https://ncbi.nlm.nih.gov/pubmed/21892162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.913
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