Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease

BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder that causes progressive memory and cognitive decline during middle to late adult life. The AD brain is characterized by deposition of amyloid β peptide (Aβ), which is produced from amyloid precursor protein by β- and γ-secreta...

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Hauptverfasser: Yahata, Naoki, Asai, Masashi, Kitaoka, Shiho, Takahashi, Kazutoshi, Asaka, Isao, Hioki, Hiroyuki, Kaneko, Takeshi, Maruyama, Kei, Saido, Takaomi C., Nakahata, Tatsutoshi, Asada, Takashi, Yamanaka, Shinya, Iwata, Nobuhisa, Inoue, Haruhisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184175/
https://ncbi.nlm.nih.gov/pubmed/21984949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025788
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