Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice

TRPM8 (Transient Receptor Potential Melastatin-8) is a cold- and menthol-gated ion channel necessary for the detection of cold temperatures in the mammalian peripheral nervous system. Functioning TRPM8 channels are required for behavioral responses to innocuous cool, noxious cold, injury-evoked cold...

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Bibliographic Details
Main Authors: Knowlton, Wendy M., Daniels, Richard L., Palkar, Radhika, McCoy, Daniel D., McKemy, David D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184174/
https://ncbi.nlm.nih.gov/pubmed/21984952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025894
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