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Wnt Signaling as a Potential Therapeutic Target for Frontotemporal Dementia
Progranulin mutations result in frontotemporal dementia, but the underlying pathophysiology has remained largely unexplained. New data by Geschwind and colleagues uncovered that the Wnt/FZD2 signaling pathway is an early and critical contributor to disease pathology.
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3183459/ https://ncbi.nlm.nih.gov/pubmed/21943593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.09.002 |
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