Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma

Cathepsin B and urokinase plasminogen activator receptor (uPAR) are overexpressed in gliomas. Deregulation of the G1 phase cell cycle machinery is a common feature of cancers. p27Kip1 (p27) is one of the major cyclin‐CDK regulators in the G1 phase. uPAR and cathepsin B downregulation was recently sh...

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Autores principales: Gopinath, Sreelatha, Alapati, Kiranmai, Malla, Rama Rao, Gondi, Christopher S., Mohanam, Sanjeeva, Dinh, Dzung H., Rao, Jasti S.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2011
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183416/
https://ncbi.nlm.nih.gov/pubmed/21840777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2011.07.004
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