Mesd Is A General Inhibitor of Different Wnt Ligands In Wnt/LRP Signaling and Inhibits PC-3 Tumor Growth In Vivo

Mesd is a specialized chaperone for Wnt co-receptor LRP5 and LRP6, which contain four β-propeller/EGF modules, named E1 to E4 from N- to C-terminal, in their extracellular domains. Herein, we demonstrated that recombinant Mesd protein is a general Wnt inhibitor that blocks Wnt/β-catenin signaling in...

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Bibliografiset tiedot
Päätekijät: Lin, Cuihong, Lu, Wenyan, Zhai, Ling, Bethea, Traci, Berry, Kristy, Qu, Zhican, Waud, William R., Li, Yonghe
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183310/
https://ncbi.nlm.nih.gov/pubmed/21907199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2011.08.046
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